The finding of similar short- and mid-term patency rates in both treatment groups suggests that antiplatelet therapy can be safely preferred, particularly in patients with multiple comorbidities who may face compliance issues with international normalized ratio (INR) monitoring. On the other hand, the difficulty of maintaining target INR levels in patients receiving anticoagulant therapy emerges as a crucial practical factor affecting the treatment success.[2]

Patency rates depend on anatomical and technical factors. Do the characteristics of the grafts used, such as graft material (ePTFE or Dacron), diameter, and whether they are ringed or straight, as well as the choice of graft type, show variability? From an anatomical perspective, distal vessel disease is a critical determinant of runoff. Including these details would enhance the generalizability of the study.[3,4]

I believe that this valuable study by Çelik and Şahin[1] would contribute to the development of individualized treatment approaches after peripheral arterial surgery.

Data Sharing Statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.

Conflict of Interest: The author declared no conflicts of interest with respect to the authorship and/or publication of this article.

Funding: The author received no financial support for the research and/or authorship of this article.

1) Çelik M, Şahin K. Comparison of short- and midterm outcomes of antiplatelet versus anticoagulant use in peripheral artery disease patients with synthetic grafts. Cardiovasc Surg Int 2025;12:136-41. doi:10.5606/e-cvsi.2025.1826.

2) Sargin M, Tasdemir MM, Kuplay H, Erdogan SB, Tandogar N, Akansel S, et al. Retrospective cohort study for evaluating the INR monitoring patterns in patients with deep vein thrombosis in daily practice: Analysis of 2010-2013 database of a tertiary care center. Phlebology 2019;34:317-23. doi:10.1177/0268355518806117.

3) Rychlik IJ, Davey P, Murphy J, O\'Donnell ME. A metaanalysis to compare Dacron versus polytetrafluroethylene grafts for above-knee femoropopliteal artery bypass. J Vasc Surg 2014;60:506-15. doi: 10.1016/j.jvs.2014.05.049.

4) Twine CP, McLain AD. Graft type for femoro-popliteal bypass surgery. Cochrane Database Syst Rev 2010:CD001487. doi: 10.1002/14651858.CD001487.pub2.