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Fibrosis-4 index is related to left atrial volume index in patients with acute coronary syndrome

Hüseyin Durak1, Mustafa Çetin1, Elif Ergül1, Ahmet Özsipahi1, Ahmet Yasin Tuncer1, Barış Dindar2, Ahmet Seyda Yılmaz1

1Department of Cardiology, Recep Tayyip Erdoğan University Faculty of Medicine, Rize, Türkiye
2Department of Cardiology, Uşak University Faculty of Medicine, Uşak, Türkiye

Keywords: Acute coronary syndrome, fibrosis-4 index, left atrial volume index
Objectives: This study aims to evaluate the predictive value of fibrosis-4 (FIB-4) index and left atrial (LA) indices in patients with acute coronary syndrome (ACS).

Patients and methods: Between September 2023 and March 2024, a total of 300 consecutive patients with ACS (244 males, 56 females; mean age: 62.7±11.7 years; range, 49 to 78 years) were included in the study. The study group was divided into two groups according to the LA volume index (LAVI) measurements as those with <34 mL/m2 (Group 1, n=226) and those with ≥34 mL/m2 (Group 2, n=74). Demographic, clinical and laboratory data of the patients were recorded.

Results: Among a total of 300 patients, 25.6% (n=77) were diagnosed with ST-elevation myocardial infarction (STEMI), 54% (n=162) with non-STEMI (NSTEMI), and 20.3% (n=61) with unstable angina pectoris (USAP). The FIB-4 index was positively associated with the LAVI (odds ratio [OR]=6.419; 95% confidence interval [CI]: 1.505-27.38; p=0.012). In addition, elevated FIB-4 index could predict a LAVI of ≥34 mL/m2 (area under the curve [AUC]: 0.705, p<0.001).

Conclusion: An elevated FIB-4 index is correlated with increased LAVI scores, which may serve as a well-established indicator of adverse outcomes and a reliable measure of cardiovascular risk in patients with ACS.

DOI : 10.5606/e-cvsi.2025.1789